Cold Weather Heart Attacks; Preemptive Valve Procedures Flop; Better Bleeding Score …

— Recent developments of interest in cardiovascular medicine

by Nicole Lou, Senior Staff Writer, MedPage TodayOctober 29, 2024

A Chinese study suggested that cold weather may make people more susceptible to myocardial infarction with non-obstructive coronary arteriesopens in a new tab or window compared with myocardial infarction from obstructive disease. (European Heart Journal)

Pneumonia and urinary tract infection may act as triggersopens in a new tab or window of acute myocardial infarction, according to a Danish cohort study. (European Journal of Preventive Cardiology)

People with bipolar disorder and schizophrenia had outsized risks of sudden cardiac deathopens in a new tab or window, another Danish study showed. (Heart)

For patients with systolic heart failure and moderate aortic stenosis, preemptive transcatheter aortic valve replacementopens in a new tab or window (TAVR) did not improve clinical outcomes over standard therapy in a small randomized trial. (Journal of the American College of Cardiology)

Early aortic valve intervention also failed to show clinical benefit in those with asymptomatic severe aortic stenosis and myocardial fibrosisopens in a new tab or window in a separate trial. (JAMA)

Cardiawave said its Valvosoft Non-Invasive Ultrasound Therapyopens in a new tab or window device met expectations for 6-month results in a pivotal trial of severe symptomatic calcific aortic stenosis.

A microaxial flow pumpopens in a new tab or window reduced the need for pharmacological circulatory support while maintaining hemodynamic stability in patients with ST-elevation myocardial infarction-induced cardiogenic shock, per a DanGer Shock substudy. (JAMA Cardiology)

Medtronic announced FDA approval of its Affera Mapping and Ablation System with the Sphere-9 Catheteropens in a new tab or window for radiofrequency and pulsed field ablation in persistent atrial fibrillation.

The PRECISE-HBR scoreopens in a new tab or window, which predicts post-percutaneous coronary intervention bleeding, offered a slight improvement in discrimination over existing scores. (Circulation)

Routine upfront use of orbital atherectomyopens in a new tab or window for severely (but not extremely) calcified lesions did not improve stent expansion or patient outcomes compared with routine balloon angioplasty prior to stenting, according to ECLIPSE trial results highlighted by Mount Sinai.

In a head-to-head comparison of two-stent strategies for coronary bifurcation lesions outside the left main, the double-kissing culotte techniqueopens in a new tab or window came out on top. (Circulation: Cardiovascular Interventions)

The sutureless, fully absorbable Vivasure PerQseal Closure Device Systemopens in a new tab or window performed well for large-bore vessel punctures in the PATCH IDE pivotal study, the device maker announced.

Male gender expressivityopens in a new tab or window, reflecting cultural pressures to convey masculinity, in young men was associated with fewer hypertension and diabetes diagnoses and treatment in adulthood, a cohort study suggested. (JAMA Network Open)

Two years after radiofrequency renal denervation with the Symplicity Spyral systemopens in a new tab or window, patients continued to show significant blood pressure reductions in the SPYRAL HTN-ON MED study, Medtronic said.

A first-in-human study supported an investigational cerebroprotection agent — a small-molecule adenosine A1/A3 receptor agonistopens in a new tab or window — for phase II study in stroke and traumatic brain injury. (Stroke)